Rice Institute for Biomedical Research
Department of Molecular Biosciences
Northwestern University
Lab News
Congratulations to Xiaojing Sui for receiving a Post-Doctoral Fellowship from the National Ataxia Foundation.
Congratulations to Laura Bott for her talk, A metastable protein conformational switch reveals cell state transitions in
aging and stress at the 27th Annual Midwest Stress and Molecular Chaperone Meeting in January 2022.
Congratulations to Laura Bott for her talk, A metastable protein conformational switch reveals cell state transitions in aging and stress, at the Chicago Area Worm Meeting in December 2021.
Happy Holidays from the Morimoto Lab to you! View pictures of our holiday party here.
Congratulations to Rogan Grant for his article in Nature,
Circuits between infected macrophages and T cells in SARS CoV-2 pneumonia
Congratulations to Ambre Sala for her article in Trends in Cell Biology, Protecting the future: balancing proteostasis for reproduction
Congratulations to Laura Bott for her talk, A metastable protein conformational switch reveals cell state transitions in aging and
stress, at the Young Scientist Symposium on Protein Quality Control on September 24, 2021!
The lab held the annual Morimoto Open in August and this year's champion was Thomas Stoeger. Max Felland was the Runner Up. Congratulations to everyone for their well-played matches.
View more photos of the Morimoto Open here.
The annual Undergraduate Symposium took place in August with undergraduate students presenting their summer research.
Max Felland and Cindy Zhao pictured.
Meet the undergraduates of the Morimoto Lab 2021-2022
The Morimoto Lab members gathered for the annual group photo in early August. More photos available under the Group Photos tab.
Congratulations to Ambre Sala for her talk during the the Aging and Stress Session at the 23rd International C. elegans Virtual Conference, "Embryo Integrity Regulates Maternal Proteostasis and Stress Resilience".
Congratulatons to Laura Bott for her poster at the 23rd International C. elegans Virtual Conference, "A multi-modal fluorescent biosensor for monitoring proteostasis in stress and aging”.
Congratulations to Xiaojing Sui for her poster presentation, "Proteome remodeling: A missense mutation at a time" at the 2021 FASEB Protein Aggregation Conference and for her work to co-organize its satellite conference: NextGen Symposium on Protein Aggregation for early career researchers.
_JPG.jpg)
![MWSM_horizontal_FINAL[2].jpg](https://static.wixstatic.com/media/594a6c_287aace1a6c748ef86cd356c1a4479e1~mv2.jpg/v1/fill/w_313,h_184,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/MWSM_horizontal_FINAL%5B2%5D.jpg)
![Undergrad symposium_May2 022[35].jpg](https://static.wixstatic.com/media/594a6c_2574a7ff3e4a4546ae27c4370c34605c~mv2.jpg/v1/fill/w_405,h_540,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/Undergrad%20symposium_May2%20022%5B35%5D.jpg)
We study the regulation of the heat shock response and the function of molecular chaperones and the proteostasis network to maintain the functional health of the proteome, to ensure optimal cellular health and to promote longevity. Our current interests are: to understand how different tissues in C. elegans sense diverse forms of environmental and physiological stress and communicate proteotoxic stress signals between tissues to determine organismal health, to determine the mechanisms by which proteostasis collapse occurs in aging and the relationship between proteostasis failure and other markers of aging. These observations are used to study cell stress responses and proteostasis in patient-derived direct differentiated neurons to develop small molecule strategies to restore the proteostasis network to delay or prevent proteome mismanagement that occurs in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, ALS and other protein folding disorders.
C. elegans viewed through the microscope at the Morimoto Lab
Dr. Rick Morimoto and Lab Manager, Sue Fox, celebrate the graduation of Charlie Stark and Kyoko Kohno in June 2021.
C. elegans viewed through the microscope at the Morimoto Lab
The Proteostasis Network
Protein Quality Control (PQC) is regulated by the Proteostasis Network (PN) that controls protein synthesis, folding, transport and degradation of all proteins to ensure their stability and function. We study the properties and regulation of cell stress responses, molecular chaperones, the ubiquitin-proteasome and autophagy-lysosome system at the organismal level using C. elegans and in patient derived induced neurons to examine the mechanisms of proteotoxicity in cells and tissues against proteotoxic damage.
Aging Biology
Aging is associated with the appearance and accumulation of non-native proteins with folded states that are highly aggregation-prone and amyloidogenic. We are interested in the molecular basis of quality control failure in aging, that we have termed Proteostasis Collapse, which is associated with a functional decline in specific arms of the PN leading to protein aggregation.
Proteostasis in Neurodegenerative Diseases
Alzheimer's disease, ALS, Parkinson's disease, Huntington's disease, Frontal Temporal Dementia and other neurodegenerative diseases are all associated with age-dependent protein aggregation and cellular dysfunction. We have used both C. elegans and induced neurons to discover how protein misfolding and aggregates interferes with cellular function and to discover small molecules that enhance chaperone expression and function.
The Heat Shock Response
All cells (and organisms) respond to environmental stress such as elevated temperatures and other abiotic stressors by activation of HSF1 and selective transcriptional activation of molecular chaperones and other components of the PN. In isolated cells in tissue culture, the heat shock response (HSR) is regulated cell autonomously but in C. elegans, the HSR is regulated cell non-autonomously by the AFD sensory neuron to confer cellular healthspan and lifespan.
The Proteostasis Consortium
We share an NIH Program Project Grant from NIA on Proteostasis of Aging and Neurodegenerative Diseases together with Judith Frydman (Stanford), Jeff Kelly (Scripps), Steve Finkbeiner (UCSF), and Dan Finley (Harvard). Additional information on our research and the Proteostasis Consortium Wednesday Seminars be found at https://www.proteostasisconsortium.com/.